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Injuries bounce Nadal, Safina. Roddick upset.

Has injury ever knocked two top-2 seeds from a Grand Slam tournament? I certainly can't remember another instance. But that's the case this year, with the 2-seeds from both the men's and women's sides bowing out mid-match. Rafael Nadal was headed for an early exit before he retired, down to Andy Murray in the third, 6-3, 7-6, 3-0. The big blow came when Safina, down 5-4 in the first set, retired due to back pain. She had looked good the first few games, but the pain caught up to her quickly.

Andy Roddick, who was yet again a popular pick for an upset win, again fell short of expectations being upset by 14-seed Marin Cilic, 7-6, 6-3, 3-6, 2-6, 6-3.